Volume 3, Número 1, Ano: 2022,
Author(s): Freitas, A.F.F.; Freitas, N.S.A.; Montes, M.A.; Maia, M.M.D.
Abstract: Non-synonymous single nucleotide polymorphisms (nsSNPs) represent a common genetic variation that alters amino acids encoded in proteins. All nsSNPs can potentially affect the structure or function of expressed proteins and therefore can have an impact on complex diseases. Interleukin 6 is a cytokine that acts on the immune system, with anti-inflammatory or pro-inflammatory actions depending on the cell in which it was produced. Overproduction of this cytokine results in complications in various autoimmune diseases, such as ankylosing spondylitis and rheumatoid arthritis. From genetic sequence research in the Ensembl database and software for protein analysis, it was possible to locate five missenses’ mutations (rs1282201857, rs1583431936, rs1257406129, rs756681741 and rs2069849) that affect the expression of the IL6 gene, whose impact leads to the emergence of complex diseases.
Keywords: IL-6. Genetic polymorphisms. Autoimmune diseases. Bioinformatics. In silico. nsSNPs
Author(s): Silva, B.W.C.; Albuquerque, R.M.; Batista, E.A.; Arruda, R.T.S.; Moura, M.G.S.; Vasconcelos, B.K.C.; Santos, C.J.; Neves, I.G.A.; Medeiros, M.S.; Medeiros S.S.; Neto, P.P.S.; Felix, P.T.
Abstract: A new infectious disease responsible for the emergence of respiratory syndrome and caused by the virus called coronavirus (SARS-CoV-2) was detected in late 2019 in Wuhan. Coronaviruses are a group of viruses, belonging to the family Coronoviridae of the order Nidoviridales and are responsible for causing, mainly, respiratory and gastrointestinal tract infections. SARS-CoV-2, despite predominantly infecting birds, has been responsible for the third major coronavirus outbreak in the last 20 years. In March 2020 the World Health Organization (WHO) declared the outbreak of COVID-19 cases to be a pandemic, and in October of the same year more than 1.04 million deaths were recorded.
Keywords: SARS-CoV-2. Coronavirus. Epidemic.
Barbosa, P.M.S.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Ferreira, J.V.T.; Damasceno, R.M.P.; Baroni, B.M.L.N.; Nascimento, M.M.S.T.; Neto, F.M.A.; Silva, M.M.Q.; Álvares, E.B.S.O.
Abstract: The pandemic scenario, accompanied since the end of 2019, consisting of COVID-19 affects countries on all continents. Upon reaching South America, it expressed concerns to researchers about the simultaneous circulation of existing dengue serotypes. This is a national and international literature survey involving dengue co-infection and covid-19 in Brazil. The reference period was from April 2020 to March 2021. The descriptors used were: "Coinfection" AND "simultaneous infection" AND "Sars Cov II" AND "Arbovirus". The survey took place in the PERIODIC CAPES and Google Scholar databases in both databases. It was found that the possibility of co-infection between Dengue and COVID-19 exists, mainly in endemic areas, which may lead to a delay in the diagnosis of COVID-19 infection, producing greater dissemination of the virus and progression to death.
Keywords: Arbovirus. Co-infection. Cov Sars II
Author(s): Farias, J.E.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Costa, L.L.L.; Silva, E.V.; Neto, F.M.A.; Nery, A, H.B.; Santana, A.J.; Muniz, D.B.; Álvares, E.B.S.O.
Abstract: This research aims to describe the prevalence of schistosomiasis, in the municipality of Glória do Goitá, PE, 2010-2020. This is a cross-sectional, prospective, descriptive epidemiological study that is applied to a quantitative and qualitative approach, which will be carried out using consolidated records data from 2010 to 2020 in the municipality of Glória do Goitá, in the state of Pernambuco, about the cases registered in the Schistosomes control program system (SISPCE). The municipal health department only has information from 2019, 2020 and 2021. The information for the years 2011 - 2018 was not made available, because the system was corrupted. In addition, during the years 2019, 2020 and 2021, the population worked for investigation/diagnosis of schistostosome in in the municipality of Glória do Goitá, Pernambuco consolidates a total of 6,418 individuals; number of tests performed consolidates a total of 4,954; presenting a general proportion of positive localities in the studied period of 6.48%. With this study, it is expected to evaluate the prevalence of cases of schistosomiasis in the municipality of Glória do Goitá, in the period 2010 - 2020. In addition to publications, this research, in fulfilling its objectives, is in line with national policies on epidemiological surveys with the purpose of implementing new prophylactic measures to combat this parasite.
Keywords: Endemic Diseases. Neglected diseases. Descriptive Epidemiology. Transmission
Author(s): Fonseca, S.K.V.S.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Silva, M.C.; Silva, T.G.; Alvez, T.E.S.; Bezerra, B.J.S.; Silva, M.B.; Lima, A.M.C.M.; Álvares, E.B.S.O.
Abstract: Covid-19 is a highly infectious disease caused by the new Coronavirus, which was identified in Wuhan in China and caused covid-19, 11,821 cases and 259 deaths were recorded in the first 30 days of infection, it is known that the disease causes clinical changes, so hematology is a type of test that analyzes information about the types and amounts of components in the blood as: Red blood cells; White blood cells; Platelets. The present study aimed to present the main hematological alterations found in patients hospitalized by Covid-19. The most prevalent mild symptoms include fever and cough, while in severe patient’s respiratory failure occurs, so it is possible to observe in the blood test a significant decrease (10% - 20%) of oxygen saturation. However, it was observed that there was a prevalence of changes related to leukocytes and platelets, however, lymphopenia was also present in reports made by authors.
Keywords: Covid-19. Epidemiology. Hematology. Clinical Manifestations
Author(s): Arcanjo, T.L.A.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Silva, V.B.; Alves, S.M.F.; Santos, C.J.; Damazio, S.L.C.; Martins, I.C.; Leite, A.F.B.; Leite, A.G.B.; Lima, A.M.C.M.; Álvares, E.B.S.O.
Abstract: Dengue is a serious public health problem, described as acute febrile illness, having a benign or severe course, depending on its presentation. The study aimed to present an analytical descriptive analysis of reported dengue cases in the municipality of Vitória de Santo Antão - PE. A bank was built in the Microsoft Excel spreadsheet, exported to the SPSS program, version 21, and analyzed. To evaluate the distribution of the personal and clinical profile of the patients, the percentage frequencies were calculated and the frequency distributions were constructed. The prevalence of symptoms presented by the patients was calculated and which factors were associated with the diagnosis of dengue, constructing contingency tables and applying the Chi-square test for independence. Gross Odds Ration and confidence intervals were obtained. The factors that presented significance in the bivariate analysis were included in the multivariate analysis. For the permanence of the factors in the model, the significance level of 5% was considered. The results were significant in relation to the characterization of the factors of the personal profile of the patients, indicating a higher prevalence of the disease in men (50.1%), aged 20 to 30 years (15.9%) and brown/black color/race (85.6%). The majority were not hospitalized (89.5%), being confirmed/discarded by epidemiological clinical criterion (92.2%), had cure of the disease (99. 8%), had dengue (61.0%) and three symptoms (35.9%). It is important that health professionals correctly fill out compulsory notification forms and that epidemiological weeks are properly fed with valuable information so that actions can be implemented.
Keywords: Descriptive Analysis. Analytical Analysis. Dengue fever. Epidemiology. Health Information Systems
Author(s): E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Guimarães, E.A.; Santana, A.J.; Leite, A.G.B.; Alves, S.M.F.; Damazio, S.L.C.; Martins, I.C.; Leite, A.F.B.; Lira, A.S.S.; Silva, V.B.; Álvares, E.B.S.O.
Abstract: Dengue is considered an infectious pathogenesis of acute evolution, which in recent years has seen an increase in the number of cases, constituting a serious public health problem in the world, especially in tropical countries, where environmental conditions favor the development and proliferation of Aedes aegypti, the main vector mosquito. This study aimed to randomizer a systematic review of the literature in order to understand how the temporal space distribution of dengue cases occurs. A survey of the literature was carried out in July 2019, in the periodic databases CAPES and Google Scholar. The descriptors used were: "Temporal space distribution" AND "Dengue" AND "Geoprocessing". A total of 10 articles were selected and included according to the eligibility criteria. The inclusion criteria were articles in English, Spanish and Portuguese, in the last five years, involving analysis of the temporal space distribution of reported dengue cases. Geoprocessing techniques and geostatistics have made it possible for ecological studies to make more evident the participation of the conjunction of factors, including contextual factors, in the determination of the disease by incorporating effects of the specific characteristics of each social space. The sand-time analyses of dengue cases allowed the knowledge of the geographic distribution of the disease. As well as the techniques of analysis of time trends defined as useful areas in all studies allowed the development and construction of practices applied in the process of prevention and health promotion.
Keywords: Geoprocessing; Aedes aegypti; epidemiology
Author(s): Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Silva, R.M.M.; Silva, G.E.R.; Neto, J.S.V.; Alves, S.M.F.; Bezerra, J.G.; Silva, V.B.; Leite, A.G.B.; Bacelar, E.S.; Damazio, S.L.C.; Martins, I.C.; Leite, A.F.B.; Álvares, E.B.S.O.
Abstract: The year 2015 was considered the most epidemic regarding dengue disease in Brazil, a disease that contributes with considerable socioeconomic influence in the communities of areas indicated as endemic, affecting all social levels. This study aimed to analyze the spatial-temporal distribution of dengue case notifications in the municipality of Vitória de Santo Antão-PE. A descriptive and epidemiological study of the spatial distribution of dengue cases was conducted in the municipality of Vitória de Santo Antão in 2015. The description of the control case respected the categorization offered by the Health Surveillance Guide published in 2014 effective until the beginning of 2016 and sinan's online dictionary. As results,2,203 dengue cases were reported in the municipality of Vitória de Santo Antão, among them dengue fever was confirmed in 128, confirmation for the clinical-epidemiological criterion in 1,027; these being: economically active population (n: 857); economically non-active population (n: 515); economically active male population (n: 432); economically non-active male population (n: 242); economically active female population (n: 425); economically non-active female population (n: 273); black population (n: 1,178); non-black population (n= 194); Rank level 1(n: 1,112) and Rank level 2 (n: 257). It is concluded that the analysis of the spatial-temporal distribution of case notifications can direct public policies to more direct actions to control and combat the disease vector. The space-time approach allows the integration of demographic, economic and environmental data, promoting the interrelationship of information and various databases.
Keywords: Geoprocessing. Dengue fever. Epidemiology. Health Information Systems
Author(s): Lima, J.C.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Silva, M.C.; Silva, M.E.F.; Santiago, B.C.S.; Alves, T.E.S.; Damacena, L.P.; Muniz, D.B.; Batista, E.A.; Gomes, A.D.; Santos, E.M.L.T.; Santos, C.J.; Paiva, M.I.S.; Álvares, E.B.S.O.
Abstract: Forensic toxicology is an important tool in the materialization of crime since it is verified the presence of toxic substances that will influence the elucidation of events related to the facts investigated, such as the performance of individuals who were involved in a traffic accident, or substances that have been the cause of death. This is a bibliographic review study, that is, a survey of theoretical framework from scientific publications, this at national and international level involving the performance of the pharmacist in forensic toxicology and its importance the data collection occurred through the Coordination for the Improvement of Higher Education Personnel (CAPES) and Google Scholar. It is understood, therefore, that professionals of the forensic sciences should have continuous training, as well as guidance and ethical and legal training focused on the dilemmas and specific cases of their functions seeking to prevent biases and biases.
Keywords: Pharmaceutical Sciences. Forensic toxicology. Harmful toxics.
Author(s): Silva, R.M.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Oliveira, H.J.; Silva, M.V.L.; Moura, J.L.S.; Álvares, E.B.S.O.
Abstract: Sexual and reproductive rights are recognized through national laws, so Family Planning must be carried out by the woman and man individually or by the couple, regardless of the type of union and the option to constitute or not a family. However, it is noted the importance of Nursing in Family Planning in view of the perspective of the development of the Family Health Strategy over several decades in Brazil, where providing families with the realization of Family Planning requires humanized reception, qualified listening, theoretical-scientific knowledge, information and assistance, so that they freely decide whether or not to start and at what time this should happen. Thus, it is intended that this choice should happen in a timely manner, avoiding disproval’s not only by an unplanned pregnancy, but also by decreasing morbidity and mortality from related causes.
Keywords: Host; Nursing; Humanization; Family Planning.
Author(s): Rocha, E.V.; Chaves, M.F.S.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Gomes, V.S.; Barbosa, V.C.; Santos, M.I.; Bacelar, E.S.; Lima, A.M.C.M..; Melo, M.L.; Álvares, E.B.S.O.
Abstract: This research aims to present the process of humanized care of the multidisciplinary team implemented in the Mixed Unit Maria Gaião Guerra, located in the municipality of Glória do Goitá - PE, experienced by students duly enrolled in the Bachelor of Social Work course of the University Center of Vitória de Santo Antão - UNIVISA. The methodology was initially based on the observation made during the experience of the curricular component of Supervised Internship II, carried out in the Mixed Unit Maria Gaião Guerra, located in the municipality of Glória do Goitá - PE, regarding the process of humanized care of the multidisciplinary team implemented in the health equipment under study. Based on the National Humanization Policy and the National Health Promotion Policy, correlating the importance of both for the qualification of the practice and health promotion.
Keywords: Humanized Care; Hospital Humanization; Public Health.
Author(s): Lima, P.H.; Lima, A.F.P.S.; Silva, E.T.B.; Lima, J.B.A.S.; Bacelar, E.S.; Álvares, E.B.S.O
Abstract: Studies show that more than 80% of the garbage found in the oceans is formed by plastics, most of this recyclable is located in surface waters with 95%, then we have to the coast with approximately 83% of all this material, and finally we have the river beds that have the lowest percentage, with an estimated 49%, despite being the lowest percentage, it is stillrelevant. The aim of this research is to present and raise awareness among the community about the importance of preserving the health of the oceans and other species found in our seas. This is a bibliographic review study, that is, a survey of theoretical framework from scientific publications, which is carried out in the databases of SciELO and Latin American and Caribbean Literature on Health Sciences (Lilacs). It was noted that it is of fundamental importance the need for the development of studies and/or research directed to the toxicological effects that MPs can cause to aquatic biota and for human health as well.
Keywords: Marine debris; Marine pollution; Micro plastics.
Author(s): Bruce, J.C.S.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Silva, A.S.; Bacelar, E.S.; Santos, A.A.F.; Santos, E.M.L.T.; Bezerra, J.G.; Silva, M.T.B.; Alves, T.E.S.; Álvares, E.B.S.O.
Abstract: In December 2019, pneumonia associated with the new coronavirus appeared in Wuhan, in the first 30 days China recorded 11,821 cases and 259 deaths. This research aims to analyze the reported cases of Covid-19 in the municipality of Glória do Goitá, in the state of Pernambuco, in 2020. This is a descriptive study of documentary research and analysis of secondary data of epidemiological surveillance of the Epidemiological Bulletin of December 28, 2020, conducted in the period of May 2020, in the municipality of Glória do Goitá, in the State of Pernambuco. We confirmed 454 cases of the disease, 237 (52%) males have a higher percentage when compared to females, 217 (48%) recovered, 19 (63%) deaths. According to data published in Bulletin No. 32 COVID-19 Municipal Health Department 2020, the month of June presented a total of 85 recovered, followed by the month of December, to which it presented a total of 78 recovered. And in relation to deaths recorded during the year 2020, the month of May has the highest mortality rate, 10 deaths, while the months of September and October do not present records of death by Covid-19. Confirming a pattern of infection experienced throughout the national territory.
Keywords: Coronavirus. Pathophysiology. Sars-Cov-2.
Author(s): CCosta, E.J.B.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Silva, M.T.B.; Silva, W.C.; Silva, V.D.B.; Silva, G.E.R.; Souza, J.M.; Albuquerque, V.H.; Aguiar, A.C.; Silva, R.M.S.; Lima, C.G.O.; Bruce, J.C.S.; Costa, L.L.L.; Silva, E.V.; Barbosa, V.C.; Gomes, V.S.; Álvares, E.B.S.O.; Aguiar, M.J.L.
Abstract: This article thematizes treatments in children affected by Acute Lymphocytic Leukemia. For this, treatment in patients from low-risk and high-risk groups will be addressed to the importance of diagnosis, bringing the expected results. Aiming at the process that the child patient receives, from the diagnostic to the treatments developed to reach the cure. This study was conducted from a literature review perspective, which consists of developing a theoretical basis, in the treatment of a research problem that can be answered in the analysis of a published literature. Therefore, this article is based on obtaining the study about articles that described several cases of acute lymphocytic leukemia. During this study it was possible to understand the results through treatment of patients with different degrees of the disease, each with its peculiarities, symptoms and treatment due to the disease. It also reinforces the importance of the diagnosis for the disease to be diagnosed and the indicated treatments are effective and positive, so in this study, it was important to know and understand the treatment known by GBTLI-99 that acts by degree of patient so you could get to the results of this search.
Keywords: Pharmacotherapy. GBTLI-99 protocol. Lymphocytic leukemia in children.
Author(s): Farias, D.B.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Silva, M.T.B.; Silva, W.C.; Silva, V.D.B.; Silva, G.E.R.; Souza. J.M.; Albuquerque, V.H.; Aguiar, A.C.; Silva, R.M.S.; Lima, C.G.O.; Bruce, J.C.S.; Costa L.L.L.; Silva, E.V.; Barbosa, V.C.; Gomes, V.S.; Álvares, E.B.S.O.; Morais, R.C.S.
Abstract: Despite the difficult time, the pandemic allowed teachers to work on biology curriculum contents. The aim of this study was to present discussions about the main difficulties faced by teachers and students in relation to remote classes in the teaching of biology in the pandemic scenario. The work is an integrative literature review, carried out through the electronic bases of publications: Google Academic, Scientific Electronic Library Online (SciELO) and the Periodic Portal CAPES. Through the keywords: COVID-19; Biology Teaching; Emergency remote education; Digital technologies. The choice of articles was limited to those that met the inclusion criteria, so, after pre-reading, 10 articles were selected and used for discussion. In the end, it was remarkable that the faculty was essential in the period of the pandemic of covid-19, in the instruction of students in the face of a new educational paradigm, also emphasizing a better deepening on the subject researched.
Keywords: COVID-19. Biology Teaching. Emergency remote education. Digital technologies.
Author(s): Nascimento, V.P.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Santos, C.J.; Barbosa, V.C.; Gomes, V.S.; Silva, R.G.B.S.; Silva, J.C.; Silva, W.C.; Silva, V.D.B.; Silva, G.E.R.; Souza. J.M.; Albuquerque, V.H.; Aguiar, A.C.; Silva, M.R.S.; Lima, C.G.O.; Bruce, J.C.S.; Costa L.L.L.; Silva, E.V.; Álvares, E.B.S.O.
Abstract: This paper aims to discuss what has been written about the treatment of patients with CKD in recent years. For this, it is intended: to make a simple bibliographic survey of articles published in the years 2018-2021, to perform a brief analysis about the results and to comment on the most used treatments. After the research, it was possible to find a total of 691 articles produced in Brazil. However, some of the findings corroborated the understanding that CKD treatment occurs from two main intervention models: dialysis and kidney transplantation. It was observed with the study that the treatment modalities (RRT and TR) can cause profound impacts on the quality of life of the subject, which makes attention and attention necessary and sensitivity of health teams to better align their practices and approximate patient demands.
Keywords: Chronic Kidney Disease.
Author(s): Nascimento, E.C.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Barbosa, V.C.; Gomes, V.S.; Santos, R.G.B..; Silva, J.C.; Silva, W.C.; Silva, V.D.B.; Silva, G.E.R.; Souza. J.M.; Albuquerque, V.H.; Aguiar, A.C.; Silva, R.M.S.; Lima, C.G.O.; Bruce, J.C.S.; Costa L.L.L.; Silva, E.V.; Álvares, E.B.S.O.; Sá, R.D.
Abstract: Drug disposal is of concern to public health, as toxic waste can be considered depending on the composition and degree of toxicity. Therefore, they cannot have the same destination as waste considered common. Humans are responsible for disposal, be it expired drugs, leftovers, disuse or excess. Certainly, the impact on the environment is worrying and unprecedented, in addition advertising aimed at the sale of medicine stimulates the consumer and with this waste is generated. In the results of the present study, it can be seen that the number of people who dispose incorrectly prevails compared to the number of housings studied, thus the objective of the present study is to emphasize knowledge in general relation to the disposal of medications. For the problem of bad disposal to be solved it is necessary that the information reaches people and collection points are installed.
Keywords: Drug disposal; Environment; Pharmacist.
Author(s): Silva, M.M.G.; Lima, A.F.P.S.; Silva, E.T.B.; Silva, E.B.; Lima, J.B.A.S.; Silva, W.C.; Silva, V.D.B.; Silva, G.E.R.; Souza. J.M.; Albuquerque, V.H.; Aguiar, A.C.; Barbosa, V.C.; Gomes, V.S.; Silva, R.M.S.; Lima, C.G.O.; Bruce, J.C.S.; Costa L.L.L.; Silva, E.V.; Silva, T.C.F.; Hora, L.P.L.; Hora, C.F.; Álvares, E.B.S.O.; Aguiar, M.J.L.
Abstract: It is known that advanced chronic kidney disease in the patient leads to the need for transplantation, and, consequently, to the use of immunosuppressants, which are drugs that prevent rejection of the transplanted organ. The present work is a literature review and aims to analyze the side effects of immunosuppressants in renal transplant patients. From studies on the adverse effects of immunosuppressants in patients who have undergone kidney transplantation, it will be analyzed whether it is possible to select a combination of drugs that minimize the risk of graft rejection and protect the transplanted from aggressor agents and above all from the adverse reactions of immunosuppressants on the patient. The present work is a descriptive study carried out through bibliographic consultation, using articles between 2016 and 2021, which had as inclusion the inclusion criteria the Keywords: Kidney disease, Transplantation, Immunosuppressants and Adverse reactions; and exclusion, all that did not address the have. This work did not need to go through the Ethics Committee, because it is a literature review. It was noticed that side effects can be minimized by following the protocol of the use of immunosuppressants and that therapeutic individualization can reduce the damage caused by these medications.
Keywords: Kidney disease. Transplantation. Immunosuppressants. Adverse reactions.